Dapsone gel: uses, strength, evidence, and side effects

At a glance

U.S. status

Prescription (U.S.)

Jobs

Inflammatory acne · Adult female acne · Sensitive skin that cannot tolerate retinoids

Watch for

Turns orange-brown temporarily when layered with benzoyl peroxide. Slower and milder than retinoids; a good option when tolerability is the problem.

Access

Generic 5% gel is reasonably priced; 7.5% is often brand-only with prior authorization.

Forms and strengths

5% gel twice daily (Rx, generic)
7.5% gel once daily (Rx)

How to use it

Pea-sized amount to affected areas once or twice daily depending on strength. Apply benzoyl peroxide at a different time to avoid discoloration.

Side effects and cautions

Dryness and redness
Oiliness or peeling
Temporary orange staining with benzoyl peroxide

Get advice first if

Labeling notes hemolysis risk in G6PD deficiency is low with topical use but present; tell the prescriber about G6PD deficiency or methemoglobinemia history.

Regulatory status

FDA-approved prescription drug for acne in patients 9 (7.5%) or 12 (5%) and older.

Sources on file

These links support the claims above. Reviewed September 1, 2026. Drug labels link to DailyMed searches so the current label is always one click away.