Forms and strengths
- 1% cream (Rx, brand only)
How to use it
Thin layer twice daily to affected areas; can be combined with a retinoid or benzoyl peroxide. Judge at 12 weeks.
Side effects and cautions
- Redness and scaling
- Itching
- Rare local HPA-axis suppression signal in labeling with large-area use
Get advice first if
Not studied in pregnancy. Labeling notes potential adrenal suppression with extensive use; use as directed on the face.
Regulatory status
FDA-approved prescription drug (2020) for acne in patients 12 and older. Approved in some other markets; not available in many.
In the trends
Marketed as 'topical spironolactone'; it is a different molecule with its own trials.
Sources on file
These links support the claims above. Reviewed September 1, 2026. Drug labels link to DailyMed searches so the current label is always one click away.